Hemoproteins are a group of heme-binding proteins or enzymes, including hemoglobin, myoglobin, P450 enzyme, and peroxidase, etc. They play important roles in transporting and storing oxygen, supplying essential iron, catalyzing stereoselective oxidation reactions in prokaryotic and eukaryotic cells.
Based on their various properties, these proteins have been widely applied in the fields of food and medicine, such as food processing (porcine myoglobin and soy hemoglobin used as a food-grade coloring and flavoring agent), food preservation (lactoperoxidase used as a bioavailable bacteriostatic agent), emergency medicine (human hemoglobin used as an acellular oxygen carrier), pharmaceutical synthesis (P450 enzymes used as powerful catalysts), medical diagnosis (horseradish peroxidase used as a chemiluminescent sensor). Especially, since hemoglobin and myoglobin are closely associated with the formation of meat color and metallic taste, they will become the indispensable components in the promising plant-based and cell-based artificial meat alternatives. However, until now, most hemoproteins are obtained by chemical extraction from different sources. Even few hemoproteins can be synthesized by several microorganisms, the titer of products maintain at a lower level. In recent years, with the rapid development of synthetic biology and system biology, more and more effective technologies were applied to create microbial cell factories, which significantly improve the synthesis of hemoproteins and pave the way for their future applications.
Accept Reviews or Research articles related to the synthesis of hemoproteins by microbial cell factories for application in food and medicine.
1. The application of various microbial cell factories (eukaryotic or prokaryotic) for the expression of hemoproteins (hemoglobin, myoglobin, P450 enzyme, and peroxidase, etc.).
2. The development of food-grade synthetic tools and microbial hosts for the expression of hemoproteins.
3. The enhancement of cofactor supplements (heme, NADPH, etc.) for the expression of hemoproteins.
4. Efficient synthesis and application of hemoproteins for food processing and preservation.
5. Efficient synthesis and application of hemoproteins for medicine.
6. Efficient synthesis of natural products or medical intermediates by hemoenzymes (P450 enzymes and peroxidase, etc.) in microbial hosts.
Keywords: Hemoprotein, Hemoglobin, Myoglobin, P450 enzymes, Peroxidase, Microbial cell factories, Synthesis, Food and medicine, Application
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Hemoproteins are a group of heme-binding proteins or enzymes, including hemoglobin, myoglobin, P450 enzyme, and peroxidase, etc. They play important roles in transporting and storing oxygen, supplying essential iron, catalyzing stereoselective oxidation reactions in prokaryotic and eukaryotic cells.
Based on their various properties, these proteins have been widely applied in the fields of food and medicine, such as food processing (porcine myoglobin and soy hemoglobin used as a food-grade coloring and flavoring agent), food preservation (lactoperoxidase used as a bioavailable bacteriostatic agent), emergency medicine (human hemoglobin used as an acellular oxygen carrier), pharmaceutical synthesis (P450 enzymes used as powerful catalysts), medical diagnosis (horseradish peroxidase used as a chemiluminescent sensor). Especially, since hemoglobin and myoglobin are closely associated with the formation of meat color and metallic taste, they will become the indispensable components in the promising plant-based and cell-based artificial meat alternatives. However, until now, most hemoproteins are obtained by chemical extraction from different sources. Even few hemoproteins can be synthesized by several microorganisms, the titer of products maintain at a lower level. In recent years, with the rapid development of synthetic biology and system biology, more and more effective technologies were applied to create microbial cell factories, which significantly improve the synthesis of hemoproteins and pave the way for their future applications.
Accept Reviews or Research articles related to the synthesis of hemoproteins by microbial cell factories for application in food and medicine.
1. The application of various microbial cell factories (eukaryotic or prokaryotic) for the expression of hemoproteins (hemoglobin, myoglobin, P450 enzyme, and peroxidase, etc.).
2. The development of food-grade synthetic tools and microbial hosts for the expression of hemoproteins.
3. The enhancement of cofactor supplements (heme, NADPH, etc.) for the expression of hemoproteins.
4. Efficient synthesis and application of hemoproteins for food processing and preservation.
5. Efficient synthesis and application of hemoproteins for medicine.
6. Efficient synthesis of natural products or medical intermediates by hemoenzymes (P450 enzymes and peroxidase, etc.) in microbial hosts.
Keywords: Hemoprotein, Hemoglobin, Myoglobin, P450 enzymes, Peroxidase, Microbial cell factories, Synthesis, Food and medicine, Application
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.